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CAS RN: 401566-79-8 | 產品號碼: M3838
1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine
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| 產品號碼 | M3838 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__4H__1__8N__4 = 242.33 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive |
| CAS RN | 401566-79-8 |
| Reaxys-RN | 11638685 |
| MDL編號 | MFCD22398471 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 107.0 to 111.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 109 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
運輸資料
| HS編碼* | 2933.59-000 |
Application
A Key Synthetic Intermediates of Teneligliptin, a DPP-4 Inhibitor
[M3838] and its acetate [M3849] have been used as key synthetic intermediates of teneligliptin which is a dipeptidylpeptidase IV (DPP-4) inhibitor for use as an orally active antidiabetic agent.1-3) In 2024, Kobayashi et al. reported the synthesis of teneligliptin via a continuous-flow reductive amination of [M3838] using polysilane–Pd catalyst [D5958] or polysilane–Pt catalyst [D5959].3)
References
- 1) Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
- 2) Facile new industrial process for synthesis of teneligliptin through new intermediates and its optimization with control of impurities
- 3) Reductive N-Alkylation of Amines with Ketones Using Heterogeneous Polysilane-Palladium Catalysts under Continuous-Flow Conditions
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