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CAS RN: 826-39-1 | 產品號碼: M3503
Mecamylamine Hydrochloride
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| 產品號碼 | M3503 |
| 純度/分析方法 | >98.0%(T) |
| 分子式 / 分子量 | C__1__1H__2__1N·HCl = 203.75 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic |
| CAS RN | 826-39-1 |
| Reaxys-RN | 7097642 |
| MDL編號 | MFCD00151462 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Purity(Precipitation Titration) | min. 98.0 % |
| NMR | confirm to structure |
性質
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | RB6900000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2921.30-000 |
Application
Mecamylamine Hydrochloride: A Nicotinic Acetylcholine Receptors (nAChRs) Antagonist
Mecamylamine hydrochloride is a non-selective, non-competitive antagonist of the nicotinic acetylcholine receptors (nAChRs). It was developed as an antihypertensive agent in the 1950s, but is rarely used today for hypertension because of its widespread ganglionic side effects, and is more often now as a neuro research tool. Mecamylamine easily traverses the blood-brain barrier to reach the central nervous system (CNS), where it acts as a nicotinic acetylcholine receptor antagonist.1-5) This effect is thought to be due to antagonist effects at the α4β2 nicotinic receptors in the brain.4) Recently, it is expected to be used as an agent in treating CNS disorders, including nicotine and alcohol addiction in clinical.5) (The product is for research purpose only.)
References
- 1) Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes
- 2) Blockade of nicotine self-administration with nicotinic antagonists in rats
- 3) Nicotinic acetylcholine receptors as targets for antidepressants (a review)
- 4) TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity
- 5) Potential therapeutic uses of mecamylamine and its stereoisomers
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