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CAS RN: 790299-79-5 | 產品號碼: M3487
Masitinib
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纯度/分析方法: >95.0%(T)(HPLC)
別名
- N-[4-Methyl-3-[[4-(pyridin-3-yl)thiazol-2-yl]amino]phenyl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide
- 4-[(4-Methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl)benzamide
文件：
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| 產品號碼 | M3487 |
| 純度/分析方法 | >95.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__8H__3__0N__6OS = 498.65 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 790299-79-5 |
| Reaxys-RN | 12083382 |
| MDL編號 | MFCD09954132 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| NMR | confirm to structure |
性質
GHS
相關法規
運輸資料
| HS編碼* | 2934.10-000 |
Application
Masitinib: A Potent and Selective Inhibitor of the Receptor Tyrosine Kinase c-Kit.
The stem cell factor (SCF) receptor, c-kit receptor, is a member of the type III receptor protein tyrosine kinase (RTK) family. Masitinib (AB1010) is a potent and selective inhibitor of the receptor tyrosine kinase c-Kit.1.2) It is also an inhibitor of platelet-derived growth factor receptor alpha/beta (PDGFR α/ß), lymphocyte-specific kinase (Lck), Lck/Yes-related protein (LYn), fibroblast growth factor receptor 3 (FGFR3) and focal adhesion kinase (FAK).2) Masitinib was originally developed for the treatment of cancer, mastocytosis and inflammatory diseases as a molecularly targeted drug. Recently, masitinib has also attracted attention as a treatment for neurodegenerative diseases such as Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS).3,4) (The product is for research use only.)
References
- 1) Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
- 2) Masitinib (AB1010), from canine tumor model to human clinical development: Where we are? (a review)
- 3) Masitinib for the Treatment of Alzheimer’s disease (a review)
- 4) Masitinib: The promising actor in the next season of the Amyotrophic Lateral Sclerosis treatment series
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