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CAS RN: 338967-87-6 | 產品號碼: M3108
| 產品號碼 | M3108 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__1__5H__1__0Cl__2N__2O__2S = 353.22 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 10MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 338967-87-6 |
| Reaxys-RN | 23802926 |
| PubChem Substance ID | 354335750 |
| MDL編號 | MFCD00974506 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
性質
| 熔點 | 289 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.79-000 |
Application
Mdivi-1: A Selective Cell-Permeable Inhibitor of Mitochondrial Fission
Mitochondria play a key role in maintaining cellular metabolic homeostasis, and its fission and fusion play important roles in in several pathological conditions. Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp-1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders.
Mdivi-1 (mitochondrial division inhibitor 1) has been reported to inhibit selectively Drp-1 dependent fission with cell permeability. Inhibiting mitochondrial fission with Mdivi-1 has proven cytoprotective benefits in several cell types involved in a wide array of cardiovascular injury models. (The product is for research purpose only.)
Mdivi-1 (mitochondrial division inhibitor 1) has been reported to inhibit selectively Drp-1 dependent fission with cell permeability. Inhibiting mitochondrial fission with Mdivi-1 has proven cytoprotective benefits in several cell types involved in a wide array of cardiovascular injury models. (The product is for research purpose only.)
References
- Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
- Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
- Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine (a review)
- Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: new insight into the role of mitophagy in cell stemness (a review)
- Mitochondrial fission - a drug target for cytoprotection or cytodestruction? (a review)
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