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CAS RN: 56392-17-7 | 產品號碼: M2555
Metoprolol Tartrate
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| 產品號碼 | M2555 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__5H__2__5NO__3·^^1/__2C__4H__6O__6 = 342.41 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 56392-17-7 |
| 相關CAS RN | 51384-51-1 |
| PubChem Substance ID | 253662413 |
| Merck Index(14) | 6151 |
| MDL編號 | MFCD00056257 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 120.0 to 124.0 °C |
| Specific rotation [a]20/D | +7.0 to +10.0 deg(C=2, H2O) |
性質
| 熔點 | 123 °C |
| 比旋光 [α]D | 9° (C=2,H2O) |
| Maximum Wavelength | 223 nm (H__2O) |
| 水溶性 | Soluble |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | UB7450100 |
運輸資料
| HS編碼* | 2922.50-000 |
Application
Metoprolol Tartrate: A Selective β1-Adrenoceptor Antagonist (β1-Blocker)
Metoprolol tartrate is a selective β1-adrenoceptor antagonist (β1-blocker) which lacks intrinsic sympathomimetic activity (ISA). Metoprolol tartrate is widely used for the treatment of mild to moderate hypertension and angina pectoris. Metoprolol is metabolised by cytochrome P-450 (CYP) isoenzymes CYP2D6 in liver. Controlled release formulations of metoprolol tartrate, and combined of metoprolol tartrate and felodipine [F0814] (a selective dihydropyridine Ca2+ channel antagonist) have been reported. (The product is for research purpose only.)
References
- Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischemic heart disease and related cardiovascular disorders (a review)
- Metoprolol: A review of its use in chronic heart failure (a review)
- Metoprolol metabolism via cytochrome P4502D6 in ethnic populations
- A sensitive assay of metoprolol and its major metabolite α-hydroxy metoprolol in human plasma and determination of dextromethorphan and its metabolite dextrorphan in urine with high performance liquid chromatography and fluorometric detection
- Development of metoprolol tartrate extended-release matrix tablet formulations for regulatory policy consideration
- Felodipine/metoprolol: a review of the fixed dose controlled release formulation in the management of essential hypertension (a review)
考研文獻
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