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CAS RN: 101152-94-7 | 產品號碼: M2133
Milnacipran Hydrochloride
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| 產品號碼 | M2133 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__5H__2__2N__2O·HCl = 282.81 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 500MG-Glass Bottle with Plastic Insert （閲覽圖片）, 50MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 101152-94-7 |
| 相關CAS RN | 92623-85-3 |
| Reaxys-RN | 6078861 |
| PubChem Substance ID | 125307702 |
| Merck Index(14) | 6194 |
| MDL編號 | MFCD00901293 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 181 °C(dec.) |
| 水溶性 | Soluble |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | GZ1014010 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2924.29-000 |
Application
Milnacipran hydrochloride: A Selective Serotonin Noradrenaline Reuptake Inhibitor (SNRI)
Milnacipran hydrochloride is a selective serotonin noradrenaline reuptake inhibitor (SNRI) which acts by inhibiting noradrenaline (norepinephrine) and serotonin (5-hydroxytrytamine; 5-HT) reuptake at presynaptic sites. Milnacipran has unique characteristics that distinguish it from the other SNRIs, venlafaxine [V0110] and duloxetine [D4223], such as inhibition of noradrenaline reuptake with approximately 3-fold higher potency in vitro than serotonin. Milnacipran has no significantt affinity for other neurotransmitter receptors, such as serotonergic, α- and β-adrenergic, muscarinic, histamine, dopamine, opioid, benzodiazepine, and γ-aminobutyric acid (GABA) receptors in vitro. Milnacipran does not inhibit the activity of human monoamine oxidases (MAO-A and MAO-B) or acetylcholinesterase. (The product is for research purpose only.)
References
- Selective serotonin/noradrenaline reuptake inhibitors (SNRIs). Pharmacology and therapeutic potential in the treatment of depressive disorders (a review)
- Neurochemical and behavioral characterization of Milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats
- Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity
- High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum
- A stability indicating U-HPLC method for milnacipran in bulk drugs and pharmaceutical dosage forms
考研文獻
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