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CAS RN: 595-33-5 | 產品號碼: M1949
Megestrol Acetate
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| 產品號碼 | M1949 |
| 純度/分析方法 | >96.0%(HPLC) |
| 分子式 / 分子量 | C__2__4H__3__2O__4 = 384.52 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 595-33-5 |
| Reaxys-RN | 1917291 |
| PubChem Substance ID | 87560201 |
| Merck Index(14) | 5805 |
| MDL編號 | MFCD00056470 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Melting point | 213.0 to 220.0 °C |
| Specific rotation [a]20/D | +9.0 to +13.0 deg(C=2, CHCl3) |
| NMR | confirm to structure |
性質
| 熔點 | 218 °C |
| 比旋光 [α]D | 11° (C=2,CHCl3) |
| 溶解性（可溶於） | Chloroform |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H351 : Suspected of causing cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | TU4075000 |
運輸資料
| HS編碼* | 2937.29-000 |
Application
Megestrol Acetate: A Semi-Synthetic Progestational Agent
Megestrol acetate and medroxyprogesterone acetate [M1964], semi-synthetic progestational agents, are effective hormonal treatments for metastatic breast cancer in postmenopausal women. The antineoplastic effect may result from inhibition of pituitary gonadotropin production and resultant decrease in estrogen secretion. Recently, megestrol acetate is often used for the treatment of anorexia and cachexia. The precise mechanism is unknown at the present time. (The product is for research purpose only.)
References
- Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megestrol acetate
- An overview of megestrol acetate for the treatment of advanced breast cancer (a review)
- Cytokine activity in cancer-related anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate (a review)
- Treating malnutrition with megestrol acetate: literature review and review of our experience (a review)
- Trace analysis of androgens and progestogens in environmental waters by ultra-performance liquid chromatography-electrospray tandem mass spectrometry
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