Maximum quantity allowed is 999
请选择数量
CAS RN: 114798-26-4 | 產品號碼: L0378
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 184 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H360 : May damage fertility or the unborn child. H317 : May cause an allergic skin reaction. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | NI6732550 |
運輸資料
| HS編碼* | 2933.29-000 |
Application
Losartan: A Reversible, Non-Competitive Antagonist of the AT1 Receptor
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE). Angiotensin II is a potent vasoconstrictor, and an important component in the pathophysiology of hypertension. Angiotensin II can activate two different receptors, AT1 and AT2. The most important vasoconstrictor action of angiotensin II are mediate trough AT1 receptors. Losartan is a prodrug, and its active metabolite (EXP3174) works as a reversible, non-competitive antagonist of the AT1 receptor. 1-3) In addition, neither losartan nor its active metabolite inhibits ACE nor do they bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. In clinical, its water-soluble potassium salt (DUP 753) [L0232] is used for the treatment of hypertension. Recently, AT1 receptor antagonists (blockers), such as losartan, are expected as therapeutics for reducing the aggressiveness and mortality from SARS-CoV-2 virus infections.4) (The product is for research purpose only.)
References
- 1) Angiotensin receptor antagonists: Focus on losartan (a review)
- 2) Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of its efficacy and safety in essential hypertension (a review)
- 3) Clinical pharmacokinetics of losartan (a review)
- 4) Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics (a review)
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。