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CAS RN: 68767-14-6 | 產品號碼: L0244
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
性質
| 熔點 | 111 °C |
| 溶解性（可溶於） | Methanol |
GHS
相關法規
運輸資料
| HS編碼* | 2916.39-000 |
Application
Loxoprofen: A Prodrug of Non-Steroidal Anti-Inflammatory Drug and a Non-Selective Cyclooxygenase Inhibitor
Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen[I0415], ketoprofen[K0038] and naproxen[M1021] among others. loxoprofen is a prodrug that is rapidly converted to its active trans-alcohol metabolite (loxoprofen-SRS) following oral administration. Loxoprofen is a non-selective cyclooxygenase inhibitor. It works by reducing the synthesis of prostaglandins from arachidonic acid. Loxoprofen has more potent analgesic activity than that of ketoprofen or naproxen. (The product is for research purpose only.)
References
- Species differences in metabolism of sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate (loxoprofen sodium), a new antiinflammatory agent
- Structural determination of rat urinary metabolites of sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate (loxoprofen sodium), a new antiinflammatory agent
- Inhibition of prostaglandin production in the inflammatory tissue by loxoprofen-Na, an anti-inflammatory prodrug
- Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites
- Simultaneous analysis of several non-steroidal anti-inflammatory drugs in human urine by high-performance liquid chromatography with normal solid-phase extraction
- Rapid and simultaneous determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS with solid-phase extraction
考研文獻
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