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CAS RN: 134678-17-4 | 產品號碼: L0217
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | L0217 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__8H__1__1N__3O__3S = 229.25 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (<0°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 134678-17-4 |
| Reaxys-RN | 5480511 |
| PubChem Substance ID | 87560180 |
| Merck Index(14) | 5352 |
| MDL編號 | MFCD00869739 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 175.0 to 179.0 °C |
| Specific rotation [a]20/D | -137.0 to -147.0 deg(C=1, methanol) |
| NMR | confirm to structure |
性質
| 熔點 | 177 °C |
| 比旋光 [α]D | -142° (C=1,MeOH) |
| 水溶性 | Soluble |
| Degree of solubility in water | 70,000 mg/l 20 °C |
| 溶解性（可溶於） | Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H373 : May cause damage to organs through prolonged or repeated exposure. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P314 : Get medical advice/ attention if you feel unwell. |
相關法規
| RTECS # | UW7361333 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Lamivudine: An L-Nucleoside Reverse Transcriptase Inhibitor
Lamivudine is a nucleoside reverse transcriptase inhibitor that active against HIV1, HIV2, and hepatitis B. Lamivudine is a synthetic L-nucleoside analogue of the naturally occurring D-nucleoside 2’-deoxycytidine. Intracellularly, lamivudine is converted by cellular enzymes to the active metabolite, lamivudine-5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, 2’-deoxycytidine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)
References
- Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidine
- Lamivudine A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection
- New and Emerging Treatment of Chronic Hepatitis B (a review)
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