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CAS RN: 7179-49-9 | 產品號碼: L0166
Lincomycin Hydrochloride Monohydrate
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| 產品號碼 | L0166 |
| 純度/分析方法 | >98.0%(T)(qNMR) |
| 分子式 / 分子量 | C__1__8H__3__4N__2O__6S·HCl·H__2O = 461.02 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 7179-49-9 |
| 相關CAS RN | 859-18-7&154-21-2 |
| Reaxys-RN | 3580436 |
| PubChem Substance ID | 87572117 |
| Merck Index(14) | 5500 |
| MDL編號 | MFCD00167245 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 151.0 to 157.0 °C |
| Specific rotation [a]20/D | +134 to +139 deg(C=1, H2O) |
| Solubility in Water | almost transparency |
| Water | 3.7 to 4.5 % |
| NMR | confirm to structure |
性質
| 熔點 | 154 °C |
| 比旋光 [α]D | 137° (C=1,H2O) |
GHS
相關法規
| RTECS # | RH6315500 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Lincomycin Hydrochloride: A Lincosamide Antibiotic with Activity against Anaerobic Bacteria
Lincomycin hydrochloride is a lincosamide antibiotic isolated from the actinomyces Streptomyces lincolnensis. A congener compound, clindamycin [C2256], is derived from lincomycin to replace the 7-hydroxy group with a chlorine atom with inversion of chirality. Lincomycin has broad activity against anaerobic Gram-positive bacteria and anaerobic Gram-negative bacteria with a few exceptions, but less activity against most aerobic Gram-negative bacteria. Lincomycin interacts with the 50s subunit of bacterial ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Bacterial resistance to clindamycin and lincomycin may be caused by methylation of bacterial 23S ribosomal RNA.
References
- Lincomycin related antibiotics (a review)
- Comparative metabolism of lincomycin in the swine, chicken, and rat (a review)
- Lincomycin, clindamycin and their applications (a review)
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