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CAS RN: 155270-99-8 | 產品號碼: I1100
| 產品號碼 | I1100 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__0H__2__4N__4O__4 = 384.44 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 155270-99-8 |
| Reaxys-RN | 7863436 |
| PubChem Substance ID | 468592093 |
| MDL編號 | MFCD00928421 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 191.0 to 195.0 °C |
性質
| 熔點 | 193 °C |
| Maximum Wavelength | 362 nm (CH__2Cl__2) |
| 水溶性 | Insoluble |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | UO8414732 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Istradefylline: A Selective Adenosine A2A Receptor Antagonist
Istradefylline (KW-6002) is a selective adenosine A2A receptor antagonist. Adenosine A2A receptors are a G protein-coupled receptor (GPCR), and also one of the receptors of adenosine. In the brain, adenosine A2A receptors are considered to be present specifically in the basal ganglia, and are thought to be involved in the regulation of motor functions. The degeneration or abnormality observed in Parkinson's disease (PD) is believed to occur in the basal ganglia. Istradefylline as a high affinity and selectivity for A2A receptors. Reportedly, istradefylline has improved motor function in patients with advanced PD including loss of L-DOPA [D0600] efficacy. (The product is for research purpose only.)
References
- Adenosine A2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys
- Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP
- Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson’s disease (a review)
- Istradefylline: First Global Approval (a review)
TCIMail
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