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CAS RN: 70288-86-7 | 產品號碼: I0819
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | I0819 |
| 純度/分析方法 | >93.0%(HPLC) |
| 分子式 / 分子量 | C__4__8H__7__4O__1__4 = 875.11 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 70288-86-7 |
| Reaxys-RN | 8400552 |
| PubChem Substance ID | 468592054 |
| Merck Index(14) | 5248 |
| MDL編號 | MFCD00869511 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 93.0 area% |
| NMR | confirm to structure |
性質
| 熔點 | 155 °C |
| 溶解性（可溶於） | Diethyl ether, Ethanol, Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H300 : Fatal if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. H410 : Very toxic to aquatic life with long lasting effects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P273 : Avoid release to the environment. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | IH7891500 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | I |
| HS編碼* | 2932.20-000 |
Application
Autophagy research / Mitophagy research
References
- Ivermectin induces mitophagy in H9c2 cells via activation of the PINK1/Parkin pathway
- Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
- Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform
Application
Ivermectin: A Semisynthetic Anthelmintic Agent with Antiviral Activity
Ivermectin is a semisynthetic anthelmintic agent derived from the avermectins isolated from the fermentation products of Streptomyces avermitilis.1,2) Ivermectin contains B1a (C48H74O14) and B1b (C47H72O14), but the main component is B1a as shown in the figure. The mechanism of action of ivermectin is not fully understood, but it is strongly suggested to be related to glutamate-gated chloride channels in the muscles and nerves of nematode.2) Ivermectin binds with high affinity to glutamatergic chloride channels of nematode. As the result, the nematode is thought to be paralyzed. In addition, it has recently been reported that ivermectin has a broad spectrum of antiviral activity in vitro, including SARS-CoV-2.3,4) (The product is for research purpose only.)
References
- 1) Ivermectin 'Wonder drug' from Japan: the human use perspective (a review)
- 2) Ivermectin - Old Drug, New Tricks? (a review)
- 3) Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture
- 4) The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
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