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CAS RN: 26807-65-8 | 產品號碼: I0730
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 167.0 to 173.0 °C |
性質
| 熔點 | 170 °C |
GHS
相關法規
| RTECS # | CV2451200 |
運輸資料
| HS編碼* | 2935.90-000 |
Application
Indapamide: A Thiazide-Like Antihypertensive/Diuretic Agent
Indapamide is a thiazide-like antihypertensive/diuretic agent. Incidentally, thiazide diuretic agents include hydrochlorothiazide [H1274] and xipamide. Indapamide molecule contains both a polar sulfamoyl chlorobenzamide moiety and a lipid-soluble methylindoline moiety. Indapamide have a mild diuretic activity and a peripheral vasodilatory effect. The mechanism of action has not been completely elucidated, but indapamide affects the distal convoluted tubules, where they inhibit Na+/Cl- cotransport in the luminal membrane of tubule cells. Thus, reabsorption of NaCl and water is inhibited. (The product is for research purpose only.)
References
- Pharmacokinetics and metabolism of indapamide: a review
- The pharmacology and clinical pharmacology of indapamide
- Pharmacological properties of indapamide: rationale for use in hypertension (a review)
- Indapamide sustained release: a review of its use in treatment of hypertension (a review)
- Comparison of spectrophotometric and an LC method for the determination perindopril and indapamide in pharmaceutical formulations
PubMed Literature
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