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CAS RN: 30414-00-7 | 產品號碼: H1866
5-(Hydroxymethyl)uridine
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| 產品號碼 | H1866 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__0H__1__4N__2O__7 = 274.23 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive |
| 包裝和容器 | 200MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 30414-00-7 |
| Reaxys-RN | 38534 |
| MDL編號 | MFCD00057401 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 164.0 to 168.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 166 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
5-(hydroxymethyl)uridine: A Base-Modified Ribonucleoside Used in SMUG1 and Epigenetics Studies
Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) is a base excision repair enzyme that not only recognizes and removes uracil and oxidized pyrimidines from DNA, but is also capable of processing modified RNA substrates.1,2) There are reports that SUMG1 contributes to rRNA quality control, in part by regulating the level of 5-(hydroxymethyl)uridine (5hmU) in the cell.1,2) It is also possible that 5-(hydroxymethyl)uridine acts as an epigenetic biomarker.3)
References
- 1) The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control
- 2) RNA metabolism guided by RNA modifications: the role of SMUG1 in rRNA quality control (a review)
- 3) Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both?
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