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CAS RN: 26833-87-4 | 產品號碼: H1775
Homoharringtonine
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產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 144.0 to 148.0 °C |
| Specific rotation | -119 to -125deg (C=0.3, CHCl3) |
| NMR | confirm to structure |
性質
| 熔點 | 146 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H300 : Fatal if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | FK0260000 |
運輸資料
| UN編號 | UN1544 |
| 類別 | 6.1 |
| 包裝類別 | II |
| HS編碼* | 2939.79-000 |
Application
Homoharringtonine: A Cephalotaxine Alkaloid with Antiviral and Anticancer Activities
Homoharringtonine is a cephalotaxine alkaloid originally found in Cephalotaxus hainanensis L.1) Homoharringtonine exhibits antiviral and anticancer activities, and immobilized ribosomes immediately after initiation of translation in eukaryotic systems. It has been reported that homoharringtonine induces apoptosis in human promyelocytic leukemic HL-60 cells.2,3) Therefore, homoharringtonine has been used for the treatment of chronic myeloid leukemia (CML). (The product is for research purpose only.)
References
- 1) Structures of harringtonine, isoharringtonine, and homoharringtonine
- 2) Homoharringtonine: history, current research, and future direction (a review)
- 3) Homoharringtonine, omacetaxine mepesuccinate, and chronic myeloid leukemia circa 2009 (a review)
- 4) From traditional Chinese medicine to traditional cancer therapy (a review)
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