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CAS RN: 22465-48-1 | 產品號碼: H1542
Hydroxocobalamin Acetate
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| 產品號碼 | H1542 |
| 純度/分析方法 | >90.0%(HPLC) |
| 分子式 / 分子量 | C__6__4H__9__1CoN__1__3O__1__6P = 1,388.41 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 22465-48-1 |
| Reaxys-RN | 19236547 |
| PubChem Substance ID | 253661238 |
| Merck Index(14) | 4809 |
| MDL編號 | MFCD00082532 |
產品規格
| Appearance | Orange to Brown to Dark red powder to crystal |
| Purity(HPLC) | min. 90.0 area% |
| Purity(Chelometric Titration) | min. 95.0 %(calcd.on dried substance) |
| Drying loss | max. 12.0 % |
性質
| Maximum Wavelength | 350 nm (AcOH buffer Sol. pH4.5) |
| 溶解性（不溶於） | Ether |
GHS
相關法規
| RTECS # | GG3740000 |
運輸資料
| HS編碼* | 2936.26-000 |
Application
Hydroxocobalamin Acetate: Long Acting Vitamin B12 Physiological Equivalent Form
Vitamin B12 exists in four major physiological equivalent forms referred to collectively as cobalamins; hydroxocobalamin acetate, cyanocobalamin [C0449], methylcobalamin [M2742], and 5’-deoxyadenosylcobalamine. An intramuscular injection of hydroxocobalamin acetate produces higher serum levels than the same dose of cyanocobalamin, and these levels are well maintained. Cobalamins function as a coenzyme in a number of reactions, including the oxidation of fatty acids and the synthesis of DNA. They also works in conjugation with folic acid [F0043] (Vitamin B9) in the synthesis of the amino acid L-methionine [M0099] and it required for normal production of red blood cells. Although cobalamins are necessary for nervous system maintenance, the mechanisms are not entirely known. Cobalamins can be used to prevent or treat pathology arising from a lack of vitamin B12. (The product is for research purpose only.)
References
- Differential effects of hydroxocobalamin on NO-mediated relaxations in rat aorta and anococcygeus muscle
- Differential effects of hydroxocobalamin on relaxations induced by nitrosothiols in rat aorta and anococcygeus muscle
- Hematopoietic Vitamins with Special Reference to Vitamin B12 and Folic Acid in Clinical Field
- H. Uchino, Acta Haemat. Jpn. 1966, 29, 491.
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