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CAS RN: 82410-32-0 | 產品號碼: G0315
Ganciclovir
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| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 5G |
NT$5,040
|
9 | 33 |
| 25G |
NT$17,480
|
5 | 聯繫我們 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on dried substance) |
| Drying loss | max. 4.0 % |
性質
| 熔點 | 250 °C(dec.) |
| Degree of solubility in water | 4.3 g/l 25 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H360 : May damage fertility or the unborn child. H340 : May cause genetic defects. H351 : Suspected of causing cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | MF8407000 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Ganciclovir: A 2’-Deoxyguanosine Analogue with Antiviral Activity against Herpes Viruses including Cytomegalovirus
Ganciclovir is a synthetic analogue of 2’-deoxyguanosine with antiviral activity against members of the herpes group such as cytomegalovirus (CMV) and some other DNA viruses. In CMV-infected cells, ganciclovir is initially phosphorylated to its monophosphate by the viral protein kinase, pUL97. Subsequently, the monophosphate s converted to ganciclovir triphosphate by cellular kinases. The triphosphate inhibits virus DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, ganciclovir interfere with herpes viral DNA synthesis and replication. As the mono-phosphorylation is largely dependent on the viral kinase, mono-phosphorylation of ganciclovir occurs preferentially in virus-infected cells. For your reference, N-Acetyl-di-O-acetylganciclovir [A3228] is a synthetic intermediate of ganciclovir. (The product is for research purpose only.)
References
- Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections
- Antiviral activity and mechanism of action of ganciclovir (a review)
- A protein kinase homolog controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
- Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1
- Antiviral drug resistance of human cytomegalovirus (a review)
Application
Studies of Gene Therapy in Cancer Research
References
- In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
- The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified
- S. M. Freeman, C. N. Abboud, K. A. Whartenby, C. H. Packman, D. S. Koeplin, F. L. Moolten, G. N. Abraham, Cancer Res. 1993, 53, 5274.
- Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins
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