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CAS RN: 28808-62-0 | 產品號碼: F1187
| 產品號碼 | F1187 |
| 純度/分析方法 | >96.0%(GC) |
| 分子式 / 分子量 | C__1__4H__1__6O__3 = 232.28 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 應避免的情況 | Heat Sensitive |
| CAS RN | 28808-62-0 |
| PubChem Substance ID | 354335647 |
| MDL編號 | MFCD11101451 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 96.0 % |
| Melting point | 114.0 to 118.0 °C |
| Specific rotation [a]20/D | -37.0 to -41.0 deg(C=1, CHCL3) |
| NMR | confirm to structure |
性質
| 熔點 | 116 °C |
| 比旋光 [α]D | -39° (C=1,CHCl3) |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | TI3767000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2932.20-000 |
Application
Fraxinellone: A Degraded Limonoid with Various Bioactivities
Fraxinellone is formed by the natural degradation of limonoids isolated from the root bark of Dictamnus. Fraxinellone has been reported to possess various bioactivities, such as anti-inflammatory, neuroprotective, and vasorelaxing activities. In additon, fraxinellone derivatives have been reported to have insecticidal activities. (The product is for research purpose only.)
References
- Limonoids and alkaloids of the root bark of Dictamnus angustifolius
- Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers
- Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice
- Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cells
- Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellon
- Synthesis and Insecticidal Activity of Some Novel Fraxinellone-Based Esters
- Simultaneous determination of limonin, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS/MS and its application to a pharmacokinetic study after oral administration of Cortex Dictamni extract
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