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CAS RN: 6990-06-3 | 產品號碼: F1007
| 產品號碼 | F1007 |
| 純度/分析方法 | >97.0%(T)(HPLC) |
| 分子式 / 分子量 | C__3__1H__4__8O__6 = 516.72 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 6990-06-3 |
| Reaxys-RN | 2197692 |
| PubChem Substance ID | 253660799 |
| Merck Index(14) | 4317 |
| MDL編號 | MFCD00865135 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | -6.0 to -10.0 deg(C=1,CHCl3) |
性質
| 熔點 | 193 °C |
| 比旋光 [α]D | -7° (C=1,CHCl3) |
| Maximum Wavelength | 204(H2O) nm |
| 溶解性（可溶於） | Dioxane, Alcohol, Chloroform, Acetone |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | RC1350000 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Fusidic Acid: An Inhibitor of the Elongation Factor G (EF-G)
Fusidic acid, a steroidal antibiotic agent, is derived from the fungus Fusidium coccineum. The elongation factor G (EF-G) catalyzes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation. Fusidic acid binds to EF-G, preventing its release from the ribosome, thus stalling bacterial protein synthesis. Fusidic acid is mainly notable for its activity against staphylococci, whether or not they are resistant to methicillin and related penicillins.
References
- Structure-activity relationships in fusidic acid-type antibiotics (a review)
- The antimicrobial activity of fusidic acid (a review)
- Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics (a review)
- Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site
- Dumb and dumber-the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus (a review)
- Characterization of Global Patterns and the Genetics of Fusidic Acid Resistance (a review)
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