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CAS RN: 153439-40-8 | 產品號碼: F0698
Fexofenadine Hydrochloride
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| 產品號碼 | F0698 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__3__2H__3__9NO__4·HCl = 538.13 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (<0°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 153439-40-8 |
| 相關CAS RN | 138452-21-8&83799-24-0 |
| Reaxys-RN | 7900041 |
| PubChem Substance ID | 87561226 |
| Merck Index(14) | 4068 |
| MDL編號 | MFCD00865710 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
性質
| 溶解性（可溶於） | Methanol |
GHS
相關法規
運輸資料
| HS編碼* | 2933.39-000 |
Application
Fexofenadine: A Second-Generation Selective Histamine H1 Receptor Antagonist
Fexofenadine is a second-generation selective histamine H1 receptor antagonist that does not cross the blood brain barrier. Fexofenadine competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked. Grapefruit and other fruit juices have recently been shown to be potent inhibitors of a number of organic anion-transporting polypeptides (OATPs) in the gastrointestinal tract. Thus, these juices decrease the absorption of fexofenadine by inhibiting the activity of OATPs. For your reference, fexofenadine is the active metabolite of terfenadine [T3977]. (The product is for research purpose only.)
References
- Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticarial
- Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans (a review)
- OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
- Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
- Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans
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