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CAS RN: 220119-17-5 | 產品號碼: E1500
| 產品號碼 | E1500 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__4__3H__6__3NO__1__1 = 769.97 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 200MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 220119-17-5 |
| Reaxys-RN | 10756416 |
| MDL編號 | MFCD31621085 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
性質
GHS
| 危險性說明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相關法規
| RTECS # | CL1199500 |
運輸資料
| HS編碼* | 2932.20-000 |
Application
Selamectin: A Macrocyclic Lactone of the Avermectin Class of Anthelmintics
Selamectin is a macrocyclic lactone of the avermectin class of anthelmintics, which includes ivermectin [I0819].1,2) The mechanism of action of selamectin is not fully understood, but it is strongly suggested to be related to glutamate-gated and GABA-gated chloride channels in nematode muscles and nerves.3,4) Selamectin binds with high affinity to the nematode’s chloride channels. As a result, the nematode is believed to be paralyzed. (The product is for research purpose only.)
References
- 1) Selamectin: a novel broad-spectrum endectocide for dogs and cats (a review)
- 2) Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs
- 3) Chloride channels as tools for developing selective insecticides (a review)
- 4) Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects (a review)
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