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CAS RN: 202409-33-4 | 產品號碼: E1492
| 產品號碼 | E1492 |
純度/分析方法 
|
>95.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__8H__1__5ClN__2O__2S = 358.84 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 202409-33-4 |
| Reaxys-RN | 8073797 |
| MDL編號 | MFCD06797512 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Melting point | 133.0 to 137.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 135 °C |
GHS
相關法規
| RTECS # | DW1762210 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Etoricoxib: A Selective Cyclooxygenase-2 (COX-2) Inhibitor
Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID), and a selective inhibitor of COX-2 (cyclooxygenase 2) with a higher COX-1 to COX-2 selectivity ratio than the other COX-2-selective inhibitors, such as rofecoxib [R0206], valdecoxib [V0133] or celecoxib [C2816]. The mechanism of action is mainly by inhibition of the enzyme COX in the arachidonic acid metabolism pathway, resulting in reduced prostaglandin synthesis. In theory, a drug that selectively inhibited COX-2 might block inflammation, pain, and fever produced by prostaglandins while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1. (The product is for research purpose only.)
References
- Etoricoxib (a review)
- Selective COX-2 inhibitors: a review of their structure-activity relationships (a review)
- RP-HPLC method for simultaneous estimation of Paracetamol and Etoricoxib from bulk and tablets
- Determination of etoricoxib in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation
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