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CAS RN: 95167-41-2 | 產品號碼: D6368
DY 131
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| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 50MG |
NT$3,640
|
聯繫我們 | 34 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
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| 產品號碼 | D6368 |
| 純度/分析方法 | >98.0%(HPLC)(qNMR) |
| 分子式 / 分子量 | C__1__8H__2__1N__3O__2 = 311.39 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive |
| CAS RN | 95167-41-2 |
| Reaxys-RN | 2765110 |
| MDL編號 | MFCD00715585 |
產品規格
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 236 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2928.00-000 |
Application
DY131: An Estrogen-Related Receptors Agonist and a Hedgehog Pathway Antagonist
DY131 is a potent and selective agonist of the estrogen-related receptors (ERRγ and ERRβ).1,2) ERRγ agonist, DY131, suppresses cancer growth and represses the expression of Wnt signaling genes.3) DY131 is also a small molecule inhibitor of Smoothened (Smo) with potential anticancer activity. Smo is a cell surface receptor that mediates sonic hedgehog (Shh) signaling to regulate gene expression through the GLI transcription factors. DY131 inhibits the activity of the Shh pathway and prevents tumor growth.4) (The product is for research use only.)
References
- 1) Identification and Structure−Activity Relationship of Phenolic Acyl Hydrazones as Selective Agonists for the Estrogen-Related Orphan Nuclear Receptors ERRβ and ERRγ
- 2) Identification of an agonist ligand for estrogen-related receptors ERRβ/γ
- 3) Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer
- 4) Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation
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