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CAS RN: 979-02-2 | 產品號碼: D4687
16-Dehydropregnenolone Acetate
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| 產品號碼 | D4687 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__2__3H__3__2O__3 = 356.51 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 979-02-2 |
| Reaxys-RN | 4712779 |
| MDL編號 | MFCD00051130 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 172.0 to 176.0 °C |
| Specific rotation [a]20/D | -38.0 to -42.0 deg(C=1,CHCl3) |
性質
| 熔點 | 174 °C |
| 比旋光 [α]D | -40° (C=1,CHCl3) |
| Maximum Wavelength | 269(EtOH) nm |
GHS
相關法規
| RTECS # | TU4156200 |
運輸資料
| HS編碼* | 2937.29-000 |
Application
16-Dehydropregnenolone acetate (16-DPA): A Versatile Building Block for Preparation of Steroidal Pharmacophores
16-Dehydropregnenolone acetate (16-DPA) is an important intermediate for preparation of dexamethasone [D1961], betamethasone [B1837], 5α-reductase inhibitors (such as finasteride [F0675]), and related other steroidal pharmacophores.
References
- Chemistry of ayurvedic crude drugs. V. Guggulu (resin from Commiphora mukul). 5 some new steroidal components and stereochemistry of guggulsterol-I at C-20 and C-22
- Synthesis and in vitro activity of some epimeric 20α-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17α-hydroxylase/C17,20-lyase and 5α-reductase
- Evaluation of new pregnane derivatives as 5α-reductase inhibitor
- New 5α-reductase inhibitors: In vitro and in vivo effects
- A Lactosylated Steroid Contributes in Vivo Therapeutic Benefits in Experimental Models of Mouse Lymphoma and Human Glioblastoma
