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CAS RN: 23651-95-8 | 產品號碼: D4235
| 產品號碼 | D4235 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__9H__1__1NO__5 = 213.19 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 200MG-Glass Bottle with Plastic Insert （閲覽圖片）, 50MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 23651-95-8 |
| Reaxys-RN | 3206912 |
| PubChem Substance ID | 253659654 |
| Merck Index(14) | 3457 |
| MDL編號 | MFCD00799030 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -38.0 to -43.0 deg(C=0.5、0.1mol/L HCl)(after drying) |
| Drying loss | max. 0.1 % |
性質
| 熔點 | 225 °C(dec.) |
| 比旋光 [α]D | -40° (C=0.5,0.1mol/L Hcl) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
| RTECS # | VT9626010 |
運輸資料
| HS編碼* | 2922.50-000 |
Application
Droxidopa: A Prodrug of L-Norepinephrine
Droxidopa (L-DOPS) is a synthetic amino acid analog that is directly metabolized to L-norepinephrine [A0906] by DOPA-decarboxylase (other name: aromatic L-amino acid decarboxylase).
L-norepinephrine is crucial for many processes in the body and brain. Dopamine-β-hydroxylase (DβH) is an enzyme that catalyzed the reaction of dopamine [A0305] to L-norepinephrine. Therefore, DβH deficiency can affects many processes, for example, the autonomic nervous system which controls involuntary body processes such as the regulation of blood pressure and body temperature.
Unlike L-norepinephrine, however, droxidopa easily crosses the blood-brain barrier. Droxidopa is a prodrug of L-norepinephrine, and is used to increase the concentrations of it in the body and brain. Although the exact mechanism of action is unknown, droxidopa is mainly used for the treatment of Parkinson’s disease and neurogenic orthostatic hypotension. (The product is for research purpose only.)
L-norepinephrine is crucial for many processes in the body and brain. Dopamine-β-hydroxylase (DβH) is an enzyme that catalyzed the reaction of dopamine [A0305] to L-norepinephrine. Therefore, DβH deficiency can affects many processes, for example, the autonomic nervous system which controls involuntary body processes such as the regulation of blood pressure and body temperature.
Unlike L-norepinephrine, however, droxidopa easily crosses the blood-brain barrier. Droxidopa is a prodrug of L-norepinephrine, and is used to increase the concentrations of it in the body and brain. Although the exact mechanism of action is unknown, droxidopa is mainly used for the treatment of Parkinson’s disease and neurogenic orthostatic hypotension. (The product is for research purpose only.)
References
- L-threo-3,4-Dihydroxyphenylserine enhanced ocular dominance plasticity in adult cats
- Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine β-hydroxylase
- The metabolism of L-DOPA and L-threo-3,4-dihydroxyphenylserine and their effects on monomania in the human brain: Analysis of the intraventricular fluid from parkinsonian patients
- L-dihydroxyphenylserine (L-DOPS): a norepinephrine prodrug
- Norepinephrine deficiency in Parkinson's disease: The case for noradrenergic enhancement (a review)
- Droxidopa in neurogenic orthostatic hypotension (a review)
考研文獻
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