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CAS RN: 78628-80-5 | 產品號碼: D2049
Terbinafine Hydrochloride
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| 產品號碼 | D2049 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__1H__2__5N·HCl = 327.90 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 78628-80-5 |
| 相關CAS RN | 91161-71-6 |
| Reaxys-RN | 5660449 |
| PubChem Substance ID | 87568500 |
| Merck Index(14) | 9156 |
| MDL編號 | MFCD00145430 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 214 °C |
GHS
相關法規
| RTECS # | QJ8600100 |
運輸資料
| HS編碼* | 2921.49-000 |
Application
Terbinafine Hydrochloride: A Potent Non-Competitive Inhibitor of Squalene Epoxidase
Terbinafine [T3677] and its hydrochloride, allylamine antifungals, are potent non-competitive inhibitors of fungal squalene epoxidase, a key enzyme in ergosterol biosynthesis. Ergosterol is an essential component of fungal cell membrane, and terbinafine inhibits ergosterol synthesis at the stage of squalene epoxidation. This results in fungal cell death primarily due to the increased membrane permeability mediated by the accumulation of high concentrations of squalene but not due to ergosterol deficiency. (The product is for research purpose only.)
References
- Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease
- Therapeutic efficacy of topically applied KP-103 against experimental tinea unguium in guinea pigs in comparison with amorolfine and terbinafine
- Fungicidal Activity Plus Reservoir Effect Allow Short Treatment Courses with Terbinafine in Tinea pedis (a review)
- Tinea capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in vitro and in vivo
- High-performance liquid chromatographic assay of terbinafine hydrochloride in tablets and creams
- Quantitative analysis of terbinafine (Lamisil) in human and minipig plasma by liquid chromatography tandem mass spectrometry
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