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CAS RN: 50-02-2 | 產品號碼: D1961
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | D1961 |
純度/分析方法 
|
>99.0%(HPLC) |
| 分子式 / 分子量 | C__2__2H__2__9FO__5 = 392.47 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 50-02-2 |
| Reaxys-RN | 3176546 |
| PubChem Substance ID | 87568418 |
| SDBS (AIST Spectral DB) | 15273 |
| Merck Index(14) | 2943 |
| MDL編號 | MFCD00064136 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Specific rotation [a]20/D | +72.0 to +80.0 deg(C=1, Dioxane) |
性質
| 熔點 | 264 °C |
| 比旋光 [α]D | 76° (C=1,Dioxane) |
| 水溶性 | Insoluble |
| Degree of solubility in water | 100 mg/l 25 °C |
| 溶解性（可溶於） | Ethanol, Chloroform, Acetone, Ether |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | TU3980000 |
運輸資料
| HS編碼* | 2937.29-000 |
Application
Autophagy research / Mitophagy research
References
- Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance
- Glucocorticoid-Induced Autophagy in Osteocytes
- Branched-chain amino acids protect against dexamethasone-induced soleus muscle atrophy in rats
- Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies
Application
Dexamethasone: A Synthetic Glucocorticoid with Potent Anti-Inflammatory Activities
Dexamethasone is a synthetic glucocorticoid compound with potent anti-inflammatory activities. Dexamethasone binds more powerfully to the glucocorticoid receptor than cortisol dose. Usually, glucocorticoid receptors (GRs) bind to heat shock protein 90 (HSP90). For the receptors, dexamethasone binding promotes dissociation of the receptor from HSP90 and conversion of the receptor to the DNA (glucocorticoid responsive element, GRE)-binding state, resulting in inducing change in regulating mRNA expression that lead to anti-inflammatory reactions. (The product is for research purpose only.)
References
- Steroid receptor interactions with heat shock protein and immunophilin chaperones (a review)
- Role of inducible cyclooxygenase (COX-2) in inflammation (a review)
- Molecular pathology of cyclooxygenase-2 in neoplasia (a review)
- Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids (a review)
- The combined dexamethasone/CRH test as a potential surrogate marker in depression (a review)
Application
iPS cell generation boosting compounds
Reference
- Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
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