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CAS RN: 54-05-7 | 產品號碼: C3730
| 產品號碼 | C3730 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__8H__2__6ClN__3 = 319.88 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 54-05-7 |
| Reaxys-RN | 482809 |
| PubChem Substance ID | 468591247 |
| Merck Index(14) | 2163 |
| MDL編號 | MFCD00024009 |
產品規格
| Appearance | White to Light yellow powder to lump |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 89.0 to 93.0 °C |
| Specific rotation | -1.0 to +1.0 deg (C=1, methanol) |
| NMR | confirm to structure |
性質
| 熔點 | 91 °C |
| Maximum Wavelength | 228(H2O) nm |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | VB2360000 |
運輸資料
| HS編碼* | 2933.49-000 |
Application
Exosome research
References
- Interfering with endolysosomal trafficking enhances release of bioactive exosomes
Application
Chloroquine: A Derivative of 4-Aminoquinoline with Autophagy Inhibitory, Antimalarial and Anticancer Activities
Chloroquine is a derivative of 4-aminoquinoline, which is an inhibitor of autophagy and has antimalarial and anticancer activities.1-3) In addition, chloroquine has been also reported to exert anti-corona viral activity, including anti-SARS-CoV-2, in vitro.4-6) The mechanism of action of chloroquine is not completely understood. But, some studies have demonstrated that chloroquine is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. In addition, while chloroquine can inhibit certain enzymes, its effect is believed to result, at least in part from its interaction with DNA. (The product is for research purpose only.)
References
- 1) Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
- 2) Antimalarial Agents: Chloroquine, Hydroxychloroquine, and Quinacrine (a review)
- 3) Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells
- 4) In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine
- 5) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- 6) Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
- 7) Chloroquine phosphate (a review on the physical properties, synthesis, metabolites, and methods of analysis)
- 8) Sensitive and rapid liquid chromatography/tandem mass spectrometric assay for the quantification of chloroquine in dog plasma
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