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CAS RN: 98753-19-6 | 產品號碼: C3007
Cefpirome Sulfate
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| 產品號碼 | C3007 |
| 純度/分析方法 | >95.0%(HPLC)(N) |
| 分子式 / 分子量 | C__2__2H__2__2N__6O__5S__2·H__2SO__4 = 612.65 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 98753-19-6 |
| 相關CAS RN | 84957-29-9 |
| Reaxys-RN | 11738005 |
| PubChem Substance ID | 253661002 |
| Merck Index(14) | 1940 |
| MDL編號 | MFCD11864966 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| Specific rotation [a]20/D | -27.0 to -33.0 deg(C=2.5,a solution prepared by addition of water to 25mL of actonitrile to make 50mL)(calcd.on anh.substance) |
| Water | max. 5.0 % |
性質
| 熔點 | 200 °C |
| 比旋光 [α]D | -30° (C=2.5,JP Method) |
| Maximum Wavelength | 265 nm (Buffer) |
| 水溶性 | Soluble |
| 溶解性（不溶於） | Ether, Ethanol |
GHS
相關法規
| RTECS # | UW8970000 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Cefpirome: A Fourth Generation Cephalosporin with Broad Spectrum of Activity and Stability to β-Lactamases
Cefpirome sulfate is a fourth generation semi-synthetic cephalosporin. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the first and second generation cephalosporins. While the mechanism of action similar to other cephalosporins (inhibition of peptidoglycan synthesis by cell walls), cefpirome has also activity against Gram-positive coccus (eg. Streptococcus pneumoniae) more than the third generation cephalosporins, regardless of penicillin susceptibility. And it has increased stability to β-lactamases compared with the first and second generation cephalosporins.
References
- Stability and degradation pattern of cefpirome (HR 810) in aqueous solution
- Comparative study of pharmacokinetics and serum bactericidal activities of cefpirome, ceftazidime, ceftriaxone, imipenem, and ciprofloxacin
- Cefpirome: a review of its antibacterial activity, pharmacokinetic properties and clinical efficacy in the treatment of severe nosocomial infections and febrile neutropenia
- Development of an analytical method for cefpirome in plasma by simplified HPLC technique and its applications
- Stability-Indicating HPLC and RP-TLC Determination of Cefpirome Sulfate with Kinetic Study
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