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CAS RN: 145040-37-5 | 產品號碼: C2635
Candesartan Cilexetil
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| 產品號碼 | C2635 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__3__3H__3__4N__6O__6 = 610.67 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片）, 200MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 145040-37-5 |
| Reaxys-RN | 7328188 |
| PubChem Substance ID | 160871141 |
| Merck Index(14) | 1739 |
| MDL編號 | MFCD00871371 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 157.0 to 163.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 159 °C |
| Maximum Wavelength | 304 nm (EtOH) |
| 溶解性（微溶於） | Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | DD6672500 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Candesartan Cilexetili: A Selective AT1 Subtype Angiotensin II Receptor Antagonist
Candesartan cilexetili, a prodrug, is hydrolyzed to candesartan during absorption from the gastrointestinal tract. The active metabolite, candesartan, acts as a selective AT1 subtype angiotensin II receptor antagonist.
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Angiotensin II can activate two different receptors, AT1 and AT2, both of which are coupled to G-protein. Angiotensin II is the principal pressor agent of the renin-angiotensin system, and the actions of it are mediate through AT1 receptors. Candesartan has much greater affinity for the AT1 receptor than for the AT2 receptor, and blocks of the AT1 receptor in many tissues by an antagonist suppressed the action of angiotensin II. Candesartan exerts a long-lasting antihypertensive action in spontaneously hypertensive rats. For your reference, [M2797] is a synthetic intermediate of candesartan cilexetili. (The product is for research purpose only.)
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Angiotensin II can activate two different receptors, AT1 and AT2, both of which are coupled to G-protein. Angiotensin II is the principal pressor agent of the renin-angiotensin system, and the actions of it are mediate through AT1 receptors. Candesartan has much greater affinity for the AT1 receptor than for the AT2 receptor, and blocks of the AT1 receptor in many tissues by an antagonist suppressed the action of angiotensin II. Candesartan exerts a long-lasting antihypertensive action in spontaneously hypertensive rats. For your reference, [M2797] is a synthetic intermediate of candesartan cilexetili. (The product is for research purpose only.)
References
- Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats
- Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice
- The angiotensin II receptor antagonist candesartan cilexetil (TCV-116) ameliorates retinal disorders in rats
PubMed Literature
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