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CAS RN: 132203-70-4 | 產品號碼: C2564
Cilnidipine
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纯度/分析方法: >98.0%(HPLC)
別名
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester
- 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
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產品規格
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 5.55 to 5.75 % |
| Melting point | 108.0 to 112.0 °C |
性質
| 熔點 | 110 °C |
GHS
相關法規
| RTECS # | US7975550 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Cilnidipine: A Long-Acting Dual Antagonist of L-Type and N-Type Ca2+ Channels
Cilnidipine (FRC-8653), a dihydropyridine derivative, is a long-acting dual antagonist of L-type Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine dilates blood vessels by L-type Ca2+ channel antagonism in the vascular smooth muscles, and consequently lower blood pressure. Cilnidipine also inhibits elevation of heart rate and blood pressure under stress by N-type Ca2+ channel antagonism in the sympathetic nerve. (The product is for research purpose only.)
References
- In vitro and ex vivo Ca-antagonistic effect of 2-methoxyethyl (E)-3-phenyl-2-propen-1-yl(±)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl) pyridine-3, 5-dicarboxylate (FRC-8653), a new dihydropyridine derivative
- Dual action of FRC8653, a novel dihydropyridine derivative, on the Ba2+ current recorded from the rabbit basilar artery
- Effect of cilnidipine, a novel dihydropyridine Ca2+-channel antagonist, on N-type Ca2+ channel in rat dorsal root ganglion neurons
- Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels
- Cilnidipine: a new generation Ca2+ channel blocker with inhibitory action on sympathetic neurotransmitter release (a review).
- Analytical methodologies for determination of cilnidipine: an overview
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