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CAS RN: 83881-52-1 | 產品號碼: C2316
Cetirizine Dihydrochloride
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| 產品號碼 | C2316 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__1H__2__5ClN__2O__3·2HCl = 461.81 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 83881-52-1 |
| 相關CAS RN | 83881-51-0 |
| Reaxys-RN | 9100316 |
| PubChem Substance ID | 87560950 |
| SDBS (AIST Spectral DB) | 52376 |
| Merck Index(14) | 2022 |
| MDL編號 | MFCD00941428 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
性質
| 熔點 | 225 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | AG0980000 |
運輸資料
| HS編碼* | 2933.59-000 |
Application
Cetirizine dihydrochloride: A Second-Generation Histamine H1-Receptor Antagonist
Cetirizine dihydrochloride is a second-generation histamine H1-receptor antagonist with a long duration of activity and low potential for interaction with drugs metabolised by the hepatic cytochrome P450 system. The active R-enantiomer of cetirizine is levocetirizine [L0264].
References
- Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines
- Molecular Properties and Pharmacokinetic Behavior of Cetirizine, a Zwitterionic H1-Receptor Antagonist
- Binding characteristics of cetirizine and levocetirizine to human H1 histamine receptors: contribution of Lys191 and Thr194
- Cetirizine: a review of its use in allergic disorders (a review)
- Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine (a review)
考研文獻
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