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CAS RN: 157141-27-0 | 產品號碼: C1500
Cyanomethylenetributylphosphorane
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| 產品號碼 | C1500 |
| 純度/分析方法 | >97.0%(T) |
| 分子式 / 分子量 | C__1__4H__2__8NP = 241.36 |
| 外觀與形狀（20°C） | Liquid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Moisture Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Ampule （閲覽圖片） |
| CAS RN | 157141-27-0 |
| Reaxys-RN | 6919233 |
| PubChem Substance ID | 87566497 |
| MDL編號 | MFCD01321151 |
產品規格
| Appearance | Yellow to Amber to Dark purple clear liquid |
| Purity(Nonaqueous Titration) | min. 97.0 % |
性質
| 比重 | 0.92 |
| 折射率 | 1.50 |
GHS
| 圖形表示 |
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| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
運輸資料
| HS編碼* | 2931.49-900 |
Application
TCI Practical Example: Mitsunobu Reaction Using Tsunoda Reagent
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Used Chemicals
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Procedure
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To a solution of 3,4-dihydro-7-hydroxy-2(1H)-quinolinone (500 mg, 3.06 mmol), 4-(2-hydroxyethyl)morpholine (0.45 mL, 3.7 mmol, 1.2 eq.) in toluene (15 mL) was added Tsunoda reagent (1.0 mL, 3.8 mmol, 1.25 eq.) at r.t. and the mixture was stirred at 100 °C for 3 hours. The solvent was removed under reduced pressure and the residue was purified by column chromatography (dichloromethane:methanol = 1:0 - 10:1 on silica gel) to give 1 as a white solid (790 mg, 93%).
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Experimenter’s Comments
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The reaction mixture was monitored by UPLC.
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Analytical Data
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Compound 1
1H NMR (270 MHz, DMSO-d6); δ 9.97 (s, 1H), 7.41 (d, 1H, J = 7.8 Hz), 6.49 (d, 1H, J = 8.1 Hz), 6.43 (d, 1H, J = 1.9 Hz), 4.00 (t, 2H, J = 5.7 Hz), 3.59-3.55 (m, 4H), 2.78 (t, 2H, J = 7.3 Hz), 2.65 (t, 2H, J = 5.7 Hz), 2.46-2.33 (m, 6H).
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Lead Reference
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- Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy
Application
New Mitsunobu Reaction (Tsunoda Reagent)
References
- Carbon-carbon bond formation with new Mitsunobu reagents
- Formation of heterocycles by the Mitsunobu reaction. Stereoselective synthesis of (+)-α-skytanthine
考研文獻
TCIMail
[TCIMAIL No.156] Mitsunobu Reaction Using Acetone Cyanohydrin[TCI Practical Example] Mitsunobu Reaction Using Tsunoda Reagent
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）