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CAS RN: 108-91-8 | 產品號碼: C0494
| 產品號碼 | C0494 |
純度/分析方法 
|
>99.0%(GC) |
| 分子式 / 分子量 | C__6H__1__3N = 99.18 |
| 外觀與形狀（20°C） | Liquid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic |
| CAS RN | 108-91-8 |
| Reaxys-RN | 471175 |
| PubChem Substance ID | 87565613 |
| SDBS (AIST Spectral DB) | 592 |
| Merck Index(14) | 2729 |
| MDL編號 | MFCD00001486 |
產品規格
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(GC) | min. 99.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
性質
| 熔點 | 18 °C |
| 沸點 | 135 °C |
| flp | 30 °C |
| 比重 | 0.87 |
| 折射率 | 1.46 |
| 水溶性 | Completely miscible |
| 溶解性（可與之混溶） | Alcohol, Ether |
| 溶解性（可溶於） | Benzene |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H314 : Causes severe skin burns and eye damage. H361 : Suspected of damaging fertility or the unborn child. H370 : Causes damage to organs. H340 : May cause genetic defects. H335 : May cause respiratory irritation. H402 : Harmful to aquatic life. H226 : Flammable liquid and vapor. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P240 : Ground/bond container and receiving equipment. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233 : Keep container tightly closed. P201 : Obtain special instructions before use. P243 : Take precautionary measures against static discharge. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P242 : Use only non-sparking tools. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
相關法規
| RTECS # | GX0700000 |
運輸資料
| UN編號 | UN2357 |
| 類別 | 8 / 3 |
| 包裝類別 | II |
| HS編碼* | 2921.30-000 |
Application
Synthesis of a Piperazine Derivative
Synthesis of 1-Cyclohexyl-4-tosylpiperazine
N,N-Bis[2-(p-tolylsulfonyloxy)ethyl]-p-toluenesulfonamide (B4136, 5.83 g, 10.3 mmol), K2CO3 (P1748, 8.00 g, 58.0 mmol), cyclohexylamine (C0494, 0.99 g, 10.0 mmol), and anhydrous CH3CN (50 mL) are added to a round-bottom flask. The mixture is heated to reflux under an N2 atmosphere for 12 h. The mixture is cooled to r.t. and filtered. The filtrate is concentrated, and the residue is purified by flash chromatography (SiO2, CH2Cl2－CH3OH－Et3N as eluent) to give 1-cyclohexyl-4-tosylpiperazine as a white solid in 83% yield (2.67 g).
N,N-Bis[2-(p-tolylsulfonyloxy)ethyl]-p-toluenesulfonamide (B4136, 5.83 g, 10.3 mmol), K2CO3 (P1748, 8.00 g, 58.0 mmol), cyclohexylamine (C0494, 0.99 g, 10.0 mmol), and anhydrous CH3CN (50 mL) are added to a round-bottom flask. The mixture is heated to reflux under an N2 atmosphere for 12 h. The mixture is cooled to r.t. and filtered. The filtrate is concentrated, and the residue is purified by flash chromatography (SiO2, CH2Cl2－CH3OH－Et3N as eluent) to give 1-cyclohexyl-4-tosylpiperazine as a white solid in 83% yield (2.67 g).
References
- One-Step Cyclization: Synthesis of N-Heteroalkyl-N′-tosylpiperazines
PubMed Literature
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