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Notice of Discontinuing the Use of Password-Protected Compressed Files | Product Document Searching Made Easy by 2D Code! | TCI Life Science News February 2025 | [Product Highlights] Chemiluminescent Reagents for... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 130-26-7 | 產品號碼: C0187
5-Chloro-8-hydroxy-7-iodoquinoline
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| 產品號碼 | C0187 |
| 純度/分析方法 | >97.0%(T) |
| 分子式 / 分子量 | C__9H__5ClINO = 305.50 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Air Sensitive |
| CAS RN | 130-26-7 |
| Reaxys-RN | 153637 |
| PubChem Substance ID | 87565356 |
| SDBS (AIST Spectral DB) | 1606 |
| Merck Index(14) | 5031 |
| MDL編號 | MFCD00006787 |
產品規格
| Appearance | Light yellow to Brown to Dark green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
性質
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | VC5075000 |
運輸資料
| HS編碼* | 2933.49-000 |
Application
Clioquinol: A Metal-Chelating Antimicrobial Agent with Neuroprotective Properties
Clioquinol was first developed in 1930s as a topical antiseptic and an oral an oral intestinal amebicide. In the early 1970s, clioquinol was withdrawn from the pharmaceutical market as an oral agent due to its association with subacute myelooptic neuropathy (SMON). Recently, clioquinol has been reported as a metal-chelating antimicrobial agent with neuroprotective properties. Metal chelation is a potential therapeutic strategy for Alzheimer's disease (AD) because zinc and copper are involved in the deposition and stabilization of β-amyloid plaques, and chelating agents can dissolve amyloid deposits in vitro and in vivo. (The product is for research purpose only.)
References
- Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
- Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders
- Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse
- Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice
考研文獻
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