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CAS RN: 20350-15-6 | 產品號碼: B3820
| 產品號碼 | B3820 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__1__6H__2__4O__4 = 280.36 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (<0°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 10MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 20350-15-6 |
| Reaxys-RN | 25191 |
| PubChem Substance ID | 468590501 |
| Merck Index(14) | 1369 |
| MDL編號 | MFCD12913297 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
性質
| 熔點 | 204 °C |
| 比旋光 [α]D | 93° (C=2,MeOH) |
| Maximum Wavelength | 215 nm (EtOH) |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | GY8410000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2932.20-000 |
Application
Autophagy research / Mitophagy research
References
- Erythroleukemia cells acquire an alternative mitophagy capability
- Discovery of Atg5/Atg7-independent alternative macroautophagy
Application
CRISPR Genome Editing / Research on regenerative medicine
Brefeldin A enhances CRISPR-mediated homology-directed repair (HDR) efficiency.
Reference
- Small molecules enhance CRISPR genome editing in pluripotent stem cells
Application
Brefeldin A: A Macrolide Lactone Antibiotic used as an Inhibitor of Protein Trafficking and Secretion
Brefeldin A (BFA) is a natural fungal macrolide lactone antibiotic. Studies has demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. Therefore, BFA has been used as a tool to inhibit protein secretion and study the secretory pathway, effects of BFA on Golgi apparatus and other subcellular systems.
References
- Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum
- Brefeldin A: insights into the control of membrane traffic and organelle structure (a review)
- Brefeldin A: deciphering an enigmatic inhibitor of secretion (a review)
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