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CAS RN: 90357-06-5 | 產品號碼: B3206
| 產品號碼 | B3206 |
純度/分析方法 
|
>98.0%(HPLC)(N) |
| 分子式 / 分子量 | C__1__8H__1__4F__4N__2O__4S = 430.37 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片）, 200MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 90357-06-5 |
| Reaxys-RN | 5364666 |
| PubChem Substance ID | 172088993 |
| Merck Index(14) | 1200 |
| MDL編號 | MFCD00869971 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 194.0 to 198.0 °C |
性質
| 熔點 | 196 °C |
| Maximum Wavelength | 270 nm (CH__3CN) |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | TX1413500 |
運輸資料
| HS編碼* | 2930.90-900 |
Application
Bicalutamide: A Non-Steroidal Androgen Receptor Antagonist
Bicalutamide (ICI 176334) and flutamide [F0663] are non-steroidal androgen receptor antagonists with antiandrogenic activity. Testosterone [T0027], the most important androgen, converted to 5α-dihydrotestosterone (DHT) [A0462] by 5α-reductase type 2 which reduces the 4,5-double bond of testosterone in prostate cells. DHT has two or three times greater androgen receptor (AR) affinity than testosterone. Upon DHT binding, the AR undergoes a conformational change and releases heat shock proteins (HSPs), resulting in mRNA expression and prostate cell proliferation. Bicalutamide acts as a potent and highly selective competitive antagonist of the AR, blocks the conversion of testosterone to DHT, and inhibits the proliferation of prostate cells. Bicalutamide and flutamide are used for the treatment of prostate cancer and other androgen-dependent conditions. For your reference, [C3607] is a synthetic intermediate of bicalutamide. (The product is for research purpose only.)
References
- ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen
- Novel Mutations of Androgen Receptor: A Possible Mechanism of Bicalutamide Withdrawal Syndrome
- Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system
- The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens
- Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor
- Isolation and characterization of process related impurities and degradation products of bicalutamide and development of RP-HPLC method for impurity profile study
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