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CAS RN: 54856-23-4 | 產品號碼: B1424
Betahistine Methanesulfonate
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 25G |
NT$4,326
|
≥40 | 0 | 下單後約2週內可以出貨 |
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| 產品號碼 | B1424 |
| 純度/分析方法 | >99.0%(T)(HPLC) |
| 分子式 / 分子量 | C__8H__1__2N__2·2CH__4O__3S = 328.40 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| CAS RN | 54856-23-4 |
| 相關CAS RN | 5638-76-6 |
| Reaxys-RN | 4043104 |
| PubChem Substance ID | 87564344 |
| MDL編號 | MFCD00143688 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Neutralization titration) | min. 99.0 % |
| Melting point | 112.0 to 115.0 °C |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
性質
| 熔點 | 112 °C |
GHS
相關法規
| RTECS # | UT2970200 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Betahistine Methanesulfonate: A Histamine H1 Receptor Agonist/H3 Antagonist
Betahistine methanesulfonate is a structural analog of histamine [H0146, dihydrochloride] that acts both as a partial histamine H1-receptor agonist and histamine H3-receptor antagonist in neuronal tissue. Betahistine increases histamine turnover and release by blocking presynaptic H3-receptors and inducing H3-receptor downregulation.1-3) Reportedly, betahistine increases in vestibular blood flow, and is used as an antivertigo agent in clinical.2,3) Recently, it has been reported that betahistine induced the recall of forgotten memories in mice.4) (The product is for research purpose only.)
References
- 1) Actions of betahistine at histamine receptors in the brain
- 2) Betahistine increases vestibular blood flow
- 3) Histamine and betahistine in the treatment of vertigo: Elucidation of mechanisms of action (a review)
- 4) Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories
- 5) LC-MS-MS analysis of 2-pyridylacetic acid, a major metabolite of betahistine: application to a pharmacokinetic study in healthy volunteers
考研文獻
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