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CAS RN: 170449-18-0 | 產品號碼: A3666
AG 1478 Hydrochloride
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 25MG |
NT$7,840
|
1 | 20 | 下單後約2週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | A3666 |
| 純度/分析方法 | >95.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__6H__1__4ClN__3O__2·HCl = 352.22 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 170449-18-0 |
| Reaxys-RN | 7452865 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Precipitation Titration) | min. 95.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 235 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.59-000 |
Application
AG 1478 Hydrochloride: An EGFR Tyrosine Kinase Inhibitor
Epidermal Growth Factor Receptor (EGFR) is a type of receptor found in cells that plays a role in various cancer-related processes such as cell proliferation, apoptosis, angiogenesis and metastasis. Increased expression of EGFR is often seen in various types of tumors and has become an important target for cancer therapy. AG 1478 hydrochloride is an EGFR tyrosine kinase inhibitor used in laboratory cancer studies. (The product is for research use only.)
References
- Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors epidermal growth factor receptors
- EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells
- Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478
- Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase
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