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CAS RN: 198904-31-3 | 產品號碼: A3469
| 產品號碼 | A3469 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__3__8H__5__2N__6O__7 = 704.87 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 198904-31-3 |
| Reaxys-RN | 8101951 |
| MDL編號 | MFCD08435966 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 200.0 to 204.0 °C |
| Specific rotation | -43.0 to -47.0 deg (C=1, ethanol) |
| NMR | confirm to structure |
性質
| 熔點 | 203 °C |
GHS
相關法規
| RTECS # | RY8694000 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Atazanavir: An Azapeptide Protease Inhibitor
Atazanavir (BMS-232632) is a human immunode ficiency virus type 1 (HIV-1) protease inhibitor that prevents the formation of mature virions in HIV-1-infected cells by inhibiting the cleavage of gag and gag-pol polyproteins.1,2) Atazanavir is often used with ritonavir [R0116], a pharmacokinetic enhancer (booster), since it is metabolized by cytochrome P450 isoenzyme 3A4 to inactive metabolites.2) It has recently been reported that atazanavir inhibits SARS-CoV-2 replication and proinflammatory cytokine production.3) (The product is for research purpose only.)
References
- 1) BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents
- 2) Atazanavir: A review of its use in the management of HIV-1 infection (a review)
- 3) Atazanavir, alone or in combination with ritonavir, inhibits SARS-CoV-2 replication and proinflammatory cytokine production
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