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CAS RN: 229975-97-7 | 產品號碼: A3411
Atazanavir Sulfate
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纯度/分析方法: >98.0%(HPLC)
別名
- Dimethyl (3S,8S,9S,12S)-9-Benzyl-3,12,di-tert-butyl-8-hydroxy-4,11-dioxo-6-(p-2-pyridylbenzyl)-2,5,6,10,13-pentaazatetradecanedioate Sulfate
- Methyl [(5S,8S,9S,14S)-8-Benzyl-5-(tert-butyl)-9-hydroxy-15,15-dimethyl-3,6,13-trioxo-11-[4-(pyridin-2-yl)benzyl]-2-oxa-4,7,11,12-tetraazahexadecan-14-yl]carbamate Sulfate
文件：
| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 100MG |
NT$5,080
|
3 | 聯繫我們 |
| 500MG |
NT$17,640
|
7 | 3 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | A3411 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__3__8H__5__2N__6O__7·H__2SO__4 = 802.94 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (<0°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 500MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 229975-97-7 |
| Reaxys-RN | 11331446 |
| PubChem Substance ID | 468590285 |
| MDL編號 | MFCD08067748 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | -44.0 to -48.0 deg(C=1, H2O:MeOH=1:1) |
| NMR | confirm to structure |
性質
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H318 : Causes serious eye damage. |
| 防範說明 | P280 : Wear eye protection/ face protection. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
相關法規
| RTECS # | RY8794000 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Atazanavir Sulfate: An Azapeptide HIV-1 Protease Inhibitor
Atazanavir sulfate (BMS-232632) is s an azapeptide protease inhibitor with high specificity for, and activity against HIV-1 protease. Atazanavir selectively inhibits the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells, thus preventing formation of mature virions. For the treatment of HIV-1 infection, atazanavir is recommended in combination with other antiretroviral agents such as ritonavir [R0116], a pharmacokinetic enhancer (booster). (The product is for research purpose only.)
References
- BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents
- Activities of atazanavir (BMS-232632) against a large panel of human immunodeficiency virus type 1 clinical isolates resistant to one or more approved protease inhibitors
- Atazanavir: A review of its use in the management of HIV-1 infection
- Atazanavir/ritonavir-based combination antiretroviral therapy for treatment of HIV-1 infection in adults (a review)
- New validated RP-HPLC method for the determination of atazanavir sulphate in bulk and dosage form
- Determination of atazanavir and other antiretroviral drugs (indinavir, amprenavir, nelfinavir and its active metabolite M8, saquinavir, ritonavir, lopinavir, nevirapine and efavirenz) plasma levels by high performance liquid chromatography with UV detection
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