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CAS RN: 94749-08-3 | 產品號碼: A3190
Salmeterol Xinafoate
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| 產品號碼 | A3190 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__5H__3__7NO__4·C__1__1H__8O__3 = 603.76 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 94749-08-3 |
| 相關CAS RN | 89365-50-4 |
| Reaxys-RN | 9833043 |
| PubChem Substance ID | 354335558 |
| Merck Index(14) | 8337 |
| MDL編號 | MFCD00897708 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of Ion-Pair) |
| Purity(Neutralization titration) | min. 98.0 % |
性質
| 熔點 | 138 °C(dec.) |
| 水溶性 | Insoluble |
| 溶解性（可溶於） | Methanol |
| 溶解性（微溶於） | Ethanol |
| 溶解性（不溶於） | Diethyl ether |
GHS
相關法規
| RTECS # | QJ1970500 |
運輸資料
| HS編碼* | 2922.50-000 |
Application
Salmeterol Xinafoate: A Selective and Long-Acting β2-Adrenergic Receptor Agonist
Salmeterol xinafoate is a selective and long-acting β2-adrenergic receptor agonist. In vitro and in vivo studies demonstrate that salmeterol is selective for β2- adrenergic receptors compared with isoproterenol [I0260], which has approximately equal agonist activity on β1 and β2- adrenergic receptors. The pharmacologic effects of β2-adrenergic receptor agonist agents, including salmeterol, attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) [A0157 (2Na salt)] to cyclic-3’,5’-adenosine monophosphate (c-AMP) [A2381, A2112 (Na salt)]. Increased c-AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of inflammatory mediators from cells, especially from mast cells.
The mechanism of action for long-acting is explained as follows. Salmeterol consists of a saligenin ethanolamine “head” with a large lipophilic “tail” or side chain. Because of the side chain is anchored at the exo-site, the active “head” portion continually attaches to and detaches from the receptor site. (The product is for research purpose only.)
The mechanism of action for long-acting is explained as follows. Salmeterol consists of a saligenin ethanolamine “head” with a large lipophilic “tail” or side chain. Because of the side chain is anchored at the exo-site, the active “head” portion continually attaches to and detaches from the receptor site. (The product is for research purpose only.)
References
- Salmeterol (a review)
- The β-Adrenoceptor (a review)
- Determination of salmeterol in metered-dose and dry-powder inhalers by reversed-phase high performance liquid chromatography
- Rapid chiral high-performance liquid chromatographic assay for salmeterol and α-hydroxysalmeterol. Application to in vitro metabolism studies
- Chiral Determination of Salbutamol, Salmeterol and Atenolol by Two-Dimensional LC-LC: Application to Urine Samples
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