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CAS RN: 170729-80-3 | 產品號碼: A3135
產品號碼 | A3135 |
純度/分析方法 | >98.0%(HPLC) |
分子式 / 分子量 | C__2__3H__2__1F__7N__4O__3 = 534.43 |
外觀與形狀(20°C) | Solid |
儲存條件 | Refrigerated (0-10°C) |
應避免的情況 | Heat Sensitive |
包裝和容器 | 100MG-Glass Bottle with Plastic Insert (閲覽圖片), 500MG-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 170729-80-3 |
Reaxys-RN | 8096869 |
PubChem Substance ID | 354334991 |
Merck Index(14) | 753 |
MDL編號 | MFCD08277635 |
產品規格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 97.0 % |
Melting point | 249.0 to 253.0 °C |
Specific rotation [a]20/D | +67.0 to +71.0 deg(C=1,MeOH) |
性質
熔點 | 252 °C |
比旋光 [α]D | 69° (C=1,MeOH) |
水溶性 | Insoluble |
溶解性(微溶於) | Ethanol |
GHS
圖形表示 |
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信號詞 | Warning |
危險性說明 | H319 : Causes serious eye irritation. H351 : Suspected of causing cancer. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P405 : Store locked up. |
相關法規
RTECS # | XZ5480400 |
運輸資料
HS編碼* | 2934.99-000 |
Application
Aprepitant: A Selective High-Affinity Antagonist of the Substance P/Neurokinin 1 (NK1) Receptors
Aprepitant is a selective high-affinity antagonist of the substance P/neurokinin 1 (NK1) receptors. Aprepitan crosses the blood barrier, and then aprepitan occupies brain NK1 receptors and blocks the binding of substance P to the receptors. (Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.) Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. Aprepitant is used for the treatment of nausea and vomiting. (The product is for research purpose only.)
References
- Aprepitant - a novel NK1-receptor antagonist (a review)
- Aprepitant: A review of its use in the prevention of chemotherapy-induced nausea and vomiting
- Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting (a review)
- Simultaneous determination of Aprepitant and two metabolites in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection
- A sensitive and rapid liquid chromatography-tandem mass spectrometry method for the quantification of the novel neurokinin-1 receptor antagonist aprepitant in rhesus macaque plasma, and cerebral spinal fluid, and human plasma with application in translational NeuroAIDs research
- A validated stability indicating RP-HPLC method for the determination of aprepitant in bulk and pharmaceutical dosage forms
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