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CAS RN: 129-56-6 | 產品號碼: A2548
Anthra[1,9-cd]pyrazol-6(2H)-one
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![Anthra[1,9-cd]pyrazol-6(2H)-one](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "Anthra[1,9-cd]pyrazol-6(2H)-one")
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| 產品號碼 | A2548 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__1__4H__8N__2O = 220.23 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 25MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 129-56-6 |
| Reaxys-RN | 746890 |
| PubChem Substance ID | 253659651 |
| MDL編號 | MFCD00022289 |
產品規格
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
性質
| 熔點 | 282 °C |
GHS
相關法規
| RTECS # | CB4585000 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
LRRK2 Inhibitory Effect of SP600125
This product (SP600125) is an inhibitor of Jun N-terminal kinase (JNK), which is a stress-activated protein kinase that can be induced by inflammatory cytokines, bacterial endotoxin, osmotic shock, UV radiation, and hypoxia. In addition, there is a report that SP600125 inhibits LRRK2 (Leucine-rich repeat kinase 2) -G2019S, which is a promising therapeutic target for the treatment of Parkinson's disease, in the low micro-molar range. (The product is for research purpose only.)
References
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- Small Molecule Kinase Inhibitors for LRRK2 and Their Application to Parkinson's Disease Models (a review)
Application
Apoptosis
References
- PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilical vein endothelial cells
- Nongenotropic, anti-apoptotic signaling of 1α,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes: MEDIATION BY Src, PHOSPHATIDYLINOSITOL 3-, AND JNK KINASES
Application
c-Jun N-Terminal Kinase (JNK) Inhibitor
References
- 1)SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
- 2)Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
- 3)A mammalian scaffold complex that selectively mediates MAP kinase activation
- 4)Scaffold proteins of MAP-kinase modules
- 5)Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1
考研文獻
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
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![SP 600125 [Optimized for Cell Culture]](/medias/Tci-300-P3160.jpg?context=bWFzdGVyfHJvb3R8MTc2MDl8aW1hZ2UvanBlZ3xhRGcyTDJnNU9TODVORGswTnpRMU16VXdNVGMwTDFSamFTMHpNREJmVURNeE5qQXVhbkJufDczNWQ4MmMyMTNjMThjZmIyMWY5NTY2MDMwOTllN2M1MTUzZjY5MGI3ZmRmZTk5NzFkNTM4NDBjZDJjZjIwMGI "SP 600125 [Optimized for Cell Culture]")