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CAS RN: 78110-38-0 | 產品號碼: A2466
| 產品號碼 | A2466 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__1__3H__1__7N__5O__8S__2 = 435.43 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 500MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 78110-38-0 |
| Reaxys-RN | 3577211 |
| PubChem Substance ID | 160871057 |
| Merck Index(14) | 925 |
| MDL編號 | MFCD00072145 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Specific rotation [a]20/D | -26.0 to -32.0 deg(C=0.5、H2O) |
性質
| 熔點 | 227 °C(dec.) |
| 比旋光 [α]D | -28° (C=0.5,H2O) |
| 溶解性（不溶於） | Ethanol |
GHS
相關法規
| RTECS # | UA2451400 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Aztreonam: The First Monobactam Antibiotic with Resistance to beta-Lactamases
Aztreonam is the first synthetic monocyclic beta-lactam antibiotic (monobactam). It has strong activity against susceptible gram-negative bacteria, including Pseudomonas aeruginosa. It has no useful activity against gram-positive bacteria or anaerobes. It is highly resistant to hydrolytic inactivation caused by plasmid-mediated or chromosomally mediated beta-lactamases, but is inactivated by extended-spectrum beta-lactamases (ESBLs).
References
- Aztreonam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use
- The new monobactams: chemistry and biology
- Carbapenems and monobactams: imipenem, meropenem, and aztreonam
- Cefepime-aztreonam: a unique double β-lactam combination for Pseudomonas aeruginosa
- Background and Rationale for Revised Clinical and Laboratory Standards Institute Interpretive Criteria (Breakpoints) for Enterobacteriaceae and Pseudomonas aeruginosa: I. Cephalosporins and Aztreonam
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