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CAS RN: 77337-73-6 | 產品號碼: A2359
Acamprosate Calcium
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| 產品號碼 | A2359 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__1__0H__2__0CaN__2O__8S__2 = 400.47 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 77337-73-6 |
| 相關CAS RN | 77337-76-9 |
| Reaxys-RN | 8945911 |
| PubChem Substance ID | 125307900 |
| SDBS (AIST Spectral DB) | 52940 |
| Merck Index(14) | 17 |
| MDL編號 | MFCD00886588 |
產品規格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Chelometric Titration) | min. 97.0 % |
性質
| 熔點 | 270 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
| RTECS # | TZ6357000 |
運輸資料
| HS編碼* | 2924.19-000 |
Application
Neuroprotective Effects of Acamprosate Calcium
Acamprosate calcium is a synthetic compound with a chemical structural similar of the endogenous amino acid homotaurine [A2602], and a structural analogue of the amino acid neurotransmitter γ-aminobutyric acid (GABA) [A0282] and the amino acid neuromodulator taurine [A0295]. The precise mechanism is not fully understood, but there is evidence to suggest that acamprosate may interact with glutamate and GABA, excitatory and inhibitory neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores this balance. Acamprosate calcium is widely used in the treatment of alcohol dependence in clinical. (The product is for research purpose only.)
References
- Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain
- The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801
- Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate(a review)
- Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action (a review)
- Validation of a capillary electrophoresis procedure for the determination of calcium in calcium acamprosate
- Analysis of acamprosate in beagle dog plasma by LC-MS-MS
考研文獻
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