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CAS RN: 106941-25-7 | 產品號碼: A2322
| 產品號碼 | A2322 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__8H__1__2N__5O__4P = 273.19 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 106941-25-7 |
| Reaxys-RN | 3561094 |
| Merck Index(14) | 151 |
| MDL編號 | MFCD00866943 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 284 °C |
GHS
相關法規
| RTECS # | SZ6563500 |
運輸資料
| HS編碼* | 2933.59-000 |
Application
An Acyclic Nucleotide Analog with Activity against DNA virus
Adefovir (9-(2-phosphonylmethoxyethyl)adenine) is an acyclic nucleotide analog with activity against DNA virus such as human hepatitis B virus (HBV), and an active metabolite of adefovir dipivoxil [A2414] which was developed for clinical use.1) There are reports that adefovir inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA.2-5) (The product is for research purpose only.)
References
- 1) Clinical pharmacokinetics of the antiviral nucleotide analogs cidofovir and adefovir (a review)
- 2) Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells
- 3) Kinetic Interaction of the Diphosphates of 9-(2-phosphonylmethoxyethyl)adenine and Other anti-HIV Active Purine Congeners with HIV Reverse Transcriptase and Human DNA Polymerases α, β and γ
- 4) Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro
- 5) Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound
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