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CAS RN: 63968-64-9 | 產品號碼: A2118
| 產品號碼 | A2118 |
| 純度/分析方法 | >97.0%(HPLC) |
| 分子式 / 分子量 | C__1__5H__2__2O__5 = 282.34 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 63968-64-9 |
| Reaxys-RN | 4194670 |
| PubChem Substance ID | 87560451 |
| Merck Index(14) | 817 |
| MDL編號 | MFCD00081057 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Melting point | 151.0 to 155.0 °C |
| Specific rotation [a]20/D | +70.0 to +80.0 deg(C=0.5, MeOH) |
性質
| 熔點 | 153 °C |
| 比旋光 [α]D | 75° (C=0.5,MeOH) |
| 溶解性（可溶於） | Methanol |
GHS
相關法規
| RTECS # | KD4170000 |
運輸資料
| HS編碼* | 2932.99-000 |
Application
Artemisinin: An Antimalarial Sesquiterpene Lactone
Artemisinin is a fast-acting and widely used antimalarial agent. Artemisinin was first isolated in 1971 from Chinese medicinal herb Artemisia annua by Tu, a Chinese scientist, who was awarded the Nobel Prize in Physiology or Medicine with Omura and Campbell in 2015. After the activity of artemisinin had been established, several analogs such as such as artemether [A2190], artesunate [A2191] and dihydroartemisinin [D3793] were developed to improve bioavailability and efficacy. Artemisinin and its analogs have high efficacy against Plasmodium falciparum in the blood stages of the disease. The exact mechanism of action is still not clear, while the endoperoxide (O-O) subunit of the trioxane ring is critical for antimalarial activity. Several lines of evidence indicate that the O-O bond is easily broken by Fe2+, generating a number of reactive radicals oxidatively damage parasite. (The product is for research purpose only.)
References
- Qinghaosu (artemisinin): an antimalarial drug from China (a review)
- Artemisinin: mechanisms of action, resistance and toxicity (a review)
- Antimalarial activity of mefloquine and qinghaosu
- Total synthesis of qinghaosu
- The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
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