Glutathione peroxidase (EC1.11.1.9, GPx) is an enzyme related with anti-oxidation in mammal bodies.1) The enzyme consists of four sub-units and contains a selenium atom per subunit.2) The selenium atom exists in the enzyme as selenocysteine residue (Sec45*) and it is proposed that the residue forms the active center of the enzyme.3) The selenocysteine residue forms a catalytic triad with two other amino acid residues, Gln79* and Trp153*.3) Based on the knowledge, small organic molecules containing selenium have been designed as a mimic of the enzyme.3) Ebselen (1) is one of such seleno-molecules and possesses GPx like activity.4,5) Therefore, 1 works as an anti-oxidant.6)
Maximum quantity allowed is 999
Please select the quantity
Selenium-containing Antioxidant
No.169(April 2016)
As shown in Table, 1 possesses interesting biological activities including anti-inflammatory activity, immuno-modulation, neuroprotective activity, etc. 1 also inhibits several enzymes such as NADPH oxidase, nitric oxide synthases, and 5- and 15-LOXs.
*The residue numbers are according to the sequence alignment of human enzyme (Human pGSHPx) reported by Ren et al.7)
References
- 1)Selenium: Biochemical role as a component of glutathione peroxidase
- 2)Glutathione peroxidase: A selenoenzyme
- 3)Functional mimics of glutathione peroxidase: Bioinspired synthetic antioxidants
- 4)A novel biologically active seleno-organic compound-I, glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen)
- 5)The early research and development of ebselen
- 6)Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant
- 7)The crystal structure of seleno-glutathione peroxidase from human plasma at 2.9 Å resolution
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.